Discovery on Target 2020

Disease Modeling | Session Track: Bioengineering Microphysiological Systems

Presentation: Structural Maturation in the Development of hiPSC-Cardiomyocyte Models for Preclinical Safety, Efficacy, and Discovery

• Time: 11:15 AM - 11:35 AM EDT

• Presenter: Dr. Nicholas Geisse, PhD | Chief Science Officer, Curi Bio

• Description: iPSC-CM model systems have relatively immature phenotypes, critically limiting their ability to model human function. Here, we will present novel, high-throughput bioengineering methods to improve the maturity and predictivity of 2D and 3D iPSC-CM model systems that can be implemented in a cell-, instrument-, and assay-agnostic manner.

• Live 20-Minute Q&A with panelists following the presentation.

• PANEL MODERATOR:

  Roger Kamm, PhD, Cecil and Ida Green Distinguished Professor of Mechanical and Biological Engineering, Departments of Mechanical Engineering and Biological Engineering, Massachusetts Institute of Technology

  
  PANELISTS:

  Nicholas Geisse, PhD, Chief Science Officer, Curi Bio

  Linda Griffith, PhD, Professor, Biological Engineering & Teaching Innovation, Massachusetts Institute of Technology

  Madhu Lal-Nag, PhD, Program Lead, Research Governance Council, Office of Translational Sciences, Center for Drug Evaluation & Research, U.S. Food and Drug Administration

  Danilo Tagle, PhD, Associate Director for Special Initiatives, National Center for Advancing Translational Sciences, National Institutes of Health

Virtual Booth

Curi Bio will be exhibiting in the virtual exhibit hall. Come say hello and learn more about our maturation technologies and safety and efficacy services!

NEW at Discovery on Target 2020:

- Mantarray Platform – Human-Relevant 3D Engineered Muscle Tissue Analysis

- ComboMat Platform – Proprietary Maturation Platform for Cardiomyocytes