Generate Clinically Relevant Functional Data with 3D Tissues
Mantarray brings tissue contractility data into your drug testing and disease modeling pipeline.
By enabling the scalable analysis of adult-like contracting engineered tissues, Mantarray empowers your discovery, safety, efficacy and potency studies for new therapeutics.
Meet Mantarray™
Automatically Extract Key Metrics
Contraction Kinetics
- Time: Contraction to Peak
- Time: Peak to Relaxation
- Twitch Width
- Contraction & Relaxation Velocity
Force
- Contractile Force
- Fraction of Max Force
- Area Under Curve
Interbeat Metrics
- Beat Period & Frequency
- Beating Frequency Irregularity
Human Tissue Models. Simple and Predictive.
Cardiac, Skeletal Muscle, and Neuromuscular Applications
Tap into the power of magnetic sensing and gain access to a scalable and flexible, end-to-end process for creating, probing and analyzing contractile tissues in the convenience of your own lab.
Simplified 3D Tissue Casting for all Experience Levels
High-throughput 24-well Data Acquisition
Built-in Customizable Electrical & Optical Stimulation
Intuitive User-friendly Software
Automated Data Capture & Analysis
Request a Personalized Mantarray Demo Quote Today!
Mantarray Software Preview (click to enlarge)
Application
Disease Modeling & Therapeutic Discovery
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Stratify between healthy and disease phenotypes with isogenic and corrected lines and advanced the discovery and validation of new therapeutics. Validate new therapies using your customized human model of muscle contractility.
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Access Curi Bio’s unique arsenal of cell lines to create your own tissue model. Lines include Duchenne Muscular Dystrophy (DMD), Myotonic Dystrophy 1 (DM1), X-linked Myotubular Myopathy (XLMTM) and more.
Application
Safety Screening
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Mantarray’s high-precision magnetic sensing can identify both acute (minutes) and chronic (days) drug effects. From adrenergic functional improvement with isoproterenol to deleterious long-term weakening with doxorubicin, evaluate the effects of your compounds in a clinically relevant fashion.
Talk to our team of experts today to learn more about our safety screening services.
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Application
Neuromuscular Junction (NMJ)
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Leverage Curi Bio’s simplified tissue casting process to study the NMJ in your own lab. Effortlessly combine Skeletal Muscle and Neurospheres and study junction transmission with our specialized consumables and equipment.
If you’re interested in more information? Read the application note and watch the webinar, or please feel free to contact our team of experts with any questions.
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Replicate standard preclinical potency assays such as the mouse lethality bioassays in the comfort of your cell culture lab. Derive human-based data and characterize NMJ-targeting drugs such as Botulinum Neurotoxin (BoNT, BOTOX) using Mantarray’s functional tissue data.
If you’re interested in more information? Read the application note or please feel free to contact our team of experts with any questions.
Mantarray Consumables
Mantarray Plate Kit
Easily Form 3D Tissues in Your Lab
With over 95% tissue formation success rate, the Mantarray Plate Kit allows for reliable and reproducible engineered tissues across 24 wells.
Mantarray Stimulation Kit
Fully Customizable Electrical Stimulation
Utilizing this lid with the Mantarray instrument enables individual stimulation protocols for each well, for both acute and long-term pacing.
MantaReady Media Kits
Optimize Your 3D Tissue Casting Experience
Curi Bio's proprietary serum-free medium provides longer culture times and stronger contractile force. Available for iPSC and Primary cell types.
More Mantarray Resources
Read Publications
Learn More About Mantarray
Ready to join the 3D tissue movement? Bring the Mantarray technology into your lab. Partner with Curi Bio.
If you are interested in learning more about how Mantarray can accelerate your research, please contact us to arrange a conversation with our team of experts.