EB 2020 | San Diego, CA
April 4 - 7, 2020
NanoSurface Bio - Booth 1308
Exhibitor Presentation: “Recreating the Extracellular Matrix in a Dish”
Date: Monday, April 6, 2020
Time: 11:30 AM - 12:00 PM
Location: Exhibition Hall Theater
Presenter: Hamed Ghazizadeh, Ph.D. - Product Manager, NanoSurface Biomedical
Note: Presentation attendees will receive a $10 voucher for Food and Beverages at the convention center!
Abstract:
Cells in the body use a variety of cues (e.g. structural, mechanical, electrical, and chemical) from the extracellular matrix (ECM) to develop and mature physiologically. These influential cues help regulate a broad spectrum of processes such as cell signaling, division, and differentiation. Many in vitro platforms seek to incorporate these cues into the cell’s microenvironment, but often fail, suffering from lack of reproducibility and incompatibility with other well-established end-point assays. Here, we demonstrate biomimetic in vitro platforms capable of reliably reproducing these essential ECM cues. These platforms markedly improve the structural and functional development of a variety of cell types, including stem cells, cardiomyocytes, muscle cells, and many more. Specifically, we show how NanoSurface Plates and Cytostretcher Cell-stretching Instruments can be utilized individually or collectively to study various model systems. The effects of cell-nanotopography interactions on adhesion, signaling, polarity, and migration across many applications such as human epithelia, cardiovascular function, and cancer biology are highlighted. Further, we describe how the differentiation of stem cells can be enhanced by providing a more biomimetic culture environment, with a particular focus on iPSC-derived cardiomyocytes and skeletal muscle cells.
NanoSurface Bio Posters at EB 2020:
Abstract Title: High-precision and Scalable Fabrication of Biomimetic Culture Environments for Replicating the Extracellular Matrix In Vitro
Poster Session Title: Extracellular Matrix and Cytoskeleton
Day of presentation: Sunday, April 5, 2020
Program Number: 621.1
Poster Board Number: F253
Poster Presentation Time: 10:15 AM - 12:15 PM
Location: San Diego Convention Center, Exhibit Halls A-D
Abstract Title: Enhancing Stem Cell-based Toxicity Assays by Engineering the Culture Niche in a High-throughput, Assay-agnostic Manner
Poster Session Title: General Toxicology
Day of presentation: Tuesday, April 7, 2020
Program Number: 947.10
Poster Board Number: C109
Poster Presentation Time: 10:00 AM - 12:00 PM
Location: San Diego Convention Center, Exhibit Halls A-D