Mantarray: Scalable Human-relevant 3D Engineered Cardiac and Skeletal Muscle Tissues for Therapeutics Discovery – Upcoming Webinar Hosted by Xtalks
Originally posted on Cision PR Web – TORONTO (PRWEB) OCTOBER 05, 2021
In this free webinar, the featured speakers will discuss how contractility can be measured using 3D engineered muscle tissues (EMTs) in a scalable format with Curi Bio’s Mantarray platform. These 3D EMTs can be generated from human induced pluripotent stem cells (iPSCs) with healthy and diseased phenotypes, allowing scientists to access clinically-relevant functional data earlier. The presentation will include the value of 2D vs. 3D assays, how to balance complexity with throughput, and the use of this novel platform for toxicity screening and disease modeling for the discovery of new therapeutics.
3D cellular models and organs-on-chips are poised to add tremendous value by providing human data earlier in the drug discovery pipeline. There is intense interest in adopting these 3D models in preclinical and translational research, but their complex implementation has remained a roadblock for many labs.
In this webinar, Curi Bio will present its Mantarray platform, which represents an easy-to-use, flexible, and scalable system for generating 3D EMTs at high-throughput with the ability to measure contractility in parallel. The platform features a novel method of casting 3D tissues that can be easily performed by nearly any cell biology researcher and can be readily adapted to a variety of cell lines and extracellular matrices. In addition, Mantarray’s novel magnetic sensing modality permits contractility measurement of 24 tissues in parallel and in real time, while the cloud data analysis portal takes the guesswork out of analyzing and comparing results across experiments.
Register for this webinar to hear an overview of the technology, along with application examples across various use cases, including:
Cardiac applications that focus on the assessment of drug toxicity for acute proarrhythmic compounds as well as for chronic structural cardiotoxicants.
Skeletal muscle applications that can achieve tetanic contractions and fatigability, as well as stain positively for muscle specific markers, including fast myosin and desmin.
Disease models generated from iPSCs, as well as patients with rare diseases such as muscular dystrophy, and tested on the platform.
Learn how these advanced 3D tissue models generated on the Mantarray platform can improve the physiological relevance of preclinical cardiac and skeletal muscle models, accelerating the discovery of new medicines.
Join Dr. Nicholas Geisse, Chief Science Officer at Curi Bio, for the live webinar on Friday, October 22, 2021 at 1pm EDT.
For more information, or to register for this event, visit Mantarray: Scalable Human-Relevant 3D-Engineered Cardiac and Skeletal Muscle Tissues for Safety and Efficacy Studies.
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