[September 2021 Newsletter] Curi News – Mantarray Detection of Drug-induced Contractile Changes

Mantarray Platform Allows

Detection of Drug-induced Contractile Changes

The magnetic detection approach of the Mantarray system can measure both acute and chronic drug responses. In this experiment, Engineered Muscle Tissues (EMTs) were treated with Doxorubicin over 7 days, either with a single bolus or a drug refreshment with medium changes every 72h (green arrows). The two highest doses of continuous exposure showed a prolonged decrease in force generation throughout the time course. Interestingly the tissue with a single bolus dose of 1 μM showed a recovery of contractile force back to control levels when the drug was washed out after 3 days.

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Upcoming Events

3D Tissues Models Summit 2021

Attend Curi Bio's presentation, given by our CSO Dr. Nicholas Geisse, titled, "3D Engineered Muscle Tissues as Models of Disease & Discovery" on September 22 at 12:30pm EST. You can also visit Curi Bio at our virtual booth.

Discovery on Target 2021

Attend Curi Bio's sponsored presentation, given by our CSO Dr. Nicholas Geisse on 3D Engineered Heart Tissues. You can also visit Curi Bio's virtual booth at DOT 2021 from September 27-30.

Safety Pharmacology Society 2021

Attend Curi Bio's poster presentation, given by our CSO Dr. Nicholas Geisse titled "High-throughput Assessment of Cardiac Safety via Contractility Measurements of 3D Engineered Heart Tissues Using a Novel Instrumentation Platform." You can also visit Curi Bio's virtual booth at SPS 2021 from October 4-8.