This study aims to elucidate the role of cell adhesion to the extracellular matrix plays in maintenance of pluripotency. Researchers used superresolution two-color interferometric photo-activated localization microscopy to examine the three-dimensional architecture of cornerstone adhesions and report vertical lamination of FA proteins. Nanopatterned plates were used to accelerate differentiation of stem cell cultures to help examine the roles of these structural elements.
Originally Published in: Nature Communications (2019) (Link to Paper)
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