Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals

This study confirmed that focal adhesions transduce physical signals from topographical cues in the ECM into changes in cellular migration. Also, that aligned collagen organization induced myofibroblast differentiation, with a concomitant upregulation in myofibroblast-specific ECM genes like Postn and FnEDa.

Source: Darrian Bugg, Ross Bretherton, Peter Kim, Emily Olszewski, Abigail Nagle, Austin E. Schumacher, Nick Chu, Jagadambika Gunaje, Cole A. DeForest, Kelly Stevens, Deok-Ho Kim, Jennifer Davis. Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals. Circulation Research, October 2020 (Link to Paper)

NanoSurface PlatesArianna KieserSeptember 4, 2020Cardiac Tissue

Nanopatterned Nafion Microelectrode Arrays for In Vitro Cardiac Electrophysiology

This publication demonstrates that nanopatterned and ion permeable polymer‐coated electrodes can be utilized for enhancing the cellular environment of excitable cells within electrode‐based assays.

Source: (Link to Paper)

NanoSurface Plates, NanoMEAArianna KieserApril 22, 2020Cardiac Tissue

Engineering Anisotropic 3D Tubular Tissues with Flexible Thermoresponsive Nanofabricated Substrates

Developed a novel method for patterning and layering individual cell sheets and casting them into 3D tubular geometries with curved surfaces.

(Link to Paper)

Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells

Source: Nisa P. Williams, Marcus Rhodehamel, Calysta Yan, Alec S.T. Smith, Alex Jiao, Charles E. Murry, Marta Scatena, Deok-Ho Kim, Engineering anisotropic 3D tubular tissues with flexible thermoresponsive nanofabricated substrates, Biomaterials, Volume 240, 2020, 119856, ISSN 0142-9612.
(Link to Paper)

NanoSurface PlatesArianna KieserFebruary 11, 2016Cardiac Tissue

Nanotopography-Guided Tissue Engineering and Regenerative Medicine

Hong Nam Kim et al. Advanced Drug Delivery Reviews ,65(4), 536–558(2013) (Link To Paper)

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